A review of research on staphylococcal phenol-soluble modulins

VernacularTitle:葡萄球菌酚溶调节肽研究现状
Author: Li TAN ¹ ; Sirui LI ; Bei JIANG ; Xiancai RAO ; Xiaomei HU ; Shu LI
Author Information

1. 第三军医大学微生物学教研室
Keywords: Phenol-soluble modulins; Staphylococcus; Virulence factor; Agr quorum-sensing sys-tem
From: Chinese Journal of Microbiology and Immunology 2018;38(3):232-236
CountryChina
Language:Chinese
Abstract: Phenol-soluble modulins (PSMs) are a novel family of small amphipathic, alpha-heli-cal peptides with strong surfactant-like properties. PSMs have multiple roles in staphylococcal pathogenesis and are considered as important virulence-associated factors. They may cause lysis of many eukaryotic cells, such as human neutrophils,erythrocytes and dendritic cells;induce the expression of pro-inflammatory cyto-kines;facilitate the structuring and detachment of biofilms;influence the expression of other genes. This re-view summarizes the classification,structure,regulatory effect on gene expression and biological function of PSMs. The potential avenues to target PSMs for drug development against staphylococcal infections are also evaluated in this paper.