Clinical study on the effect of different calcineurin inhibitors on BK virus infection after renal transplantation
10.3760/cma.j.issn.0254-1785.2018.01.001
- VernacularTitle:不同种类钙调磷酸酶抑制剂影响肾移植后BK病毒感染的临床研究
- Author:
Yu FAN
1
;
Yeyong QIAN
;
Bingyi SHI
;
Hongwei BAI
;
Yongwen LUO
Author Information
1. 解放军第三○九医院移植外科
- Keywords:
renal transplantation;
BK virus;
BK virus nephropathy;
calcineurin inhibitor
- From:
Chinese Journal of Organ Transplantation
2018;39(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of cyclosporine A (CsA) and tacrolimus (FK506) on BK virus infection after renal transplantation by retrospective clinical study.Methods The data of calcineurin inhibitor (CNI)-based immunosuppression and virus infection were collected in allograft renal transplantation recipients (n =135) from Jan.2014 to Dec.2015.According to the severity of the virus infection the recipients were divided into three groups:viruria,viremia and virus nephropathy.The difference in BK virus infection between FK506 and CsA was compared.Results A total of 135 cases of transplant recipients,postoperative were enrolled.The number of viruria recipients given FK506 and CsA was 41 cases (69.5％) and 18 cases (30.5％),and that of viremia recipients was 26 cases (86.7 ％) and 4 cases (13.3 ％).Statistical analysis showed that CNI immunosuppressive agents had a significant correlation with viremia only (P＜0.05).There was a positive correlation between FK506 and viremia (r =0.423,P =0.018),and CsA showed a negative correlation yet (r =-0.336,P =0.022).Conclusion Tacrolimus is independent risk factors for early BK viremia after kidney transplantation,and CsA may inhibit the progression of BK viremia.
