The situation and feature of the intensive insulin therapy in a group of hyperglycemic patients during pregnancy

VernacularTitle:一组强化治疗妊娠期高血糖患者的胰岛素应用状况和特点
Author: Yu CHEN ¹ ; Jingfan ZHANG ; Ping LI ; Fang ZHOU ; Cong LIU ; Ling LI
Author Information

1. 中国医科大学附属盛京医院内分泌科
Keywords: Pregestational diabetes mellitus; Gestational diabetes mellitus; Insulin intensive therapy; Hypoglycemia
From: Chinese Journal of Endocrinology and Metabolism 2018;34(4):304-307
CountryChina
Language:Chinese
Abstract: Relevant clinical data of 141 cases diagnosed pregestational diabetes mellitus(PGDM),diabetes mellitus in pregnancy(DIP), gestational diabetes mellitus(GDM), and type 2 diabetes mellitus(T2DM) were collected. The blood glucose control rate,insulin dose,and episode of hypoglycemia in the insulin intensive therapy were retrospectively analyzed. The results showed that there was no significant difference in the control rate among the four groups(P=0.906). The insulin dose/weight in GDM was significantly lower than those in PGDM,DIP,and T2DM groups[0.65(0.47-1.00),0.67(0.38-1.05),0.65(0.52-0.82)vs 0.45(0.29-0.61)U·kg-1·d-1,P<0.05 or P<0.01]. There was no significant difference in episode or incidence rate of hypoglycemia among the overall four groups(P=0.339). However in the patients with blood glucose reaching the control standard,the rate of hypoglycemia in T2DM was significantly higher than those in PGDM,DIP,and GDM(P<0.05 or P<0.01).