Effects of hearing disorder factors on analgesic efficacy of propofol
10.3760∕cma.j.issn.0254?1416.2018.01.008
- VernacularTitle:听力障碍因素对患者异丙酚镇静效应的影响
- Author:
Hongwei WANG
1
;
Dan SHEN
;
Lanlan LI
;
Long HE
;
Chenhui HE
;
Wei ZHANG
;
Yanqiu AI
;
Qinjun CHU
Author Information
1. 450052,郑州大学第一附属医院麻醉科
- Keywords:
Hearing disorders;
Propofol;
Conscious sedation
- From:
Chinese Journal of Anesthesiology
2018;38(1):52-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of hearing disorder factors on analgesic efficacy of propofol. Methods Ninety?five patients with hearing disorders, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, aged 18-60 yr, with body mass index of 20-30 kg∕m2, scheduled for elective ear surgery, served as test group(group T). Ninety?five patients with normal hearing function, of Ameri?can Society of Anesthesiologists physical status Ⅰ or Ⅱ, aged 18-60 yr, with body mass index of 20-30 kg∕m2, scheduled for elective non?ear surgery, served as control group(group C). Propofol was given at the initial target plasma concentration of 1.2 μg∕ml. When the target plasma concentration was achieved, 1 min later the concentration was increased in increments of 0.3 μg∕ml. When the patients lost eyelash reflex and had no responses to clapping on the shoulder, bispectral index value and target plasma and effect?site concentrations of propofol, consumption of propofol and time for loss of consciousness were recorded. Re?sults Compared with group C, no significant change was found in bispectral index value at baseline or at loss of consciousness(P>0.05), the target plasma and effect?site concentrations and consumption of propofol were significantly decreased, and the time for loss of consciousness was shortened in group T(P<0.05). The consumption of propofol required at loss of consciousness was gradually reduced with the aggra?vated severity of hearing disorders in group T(P<0.05). Conclusion The analgesic efficacy of propofol is enhanced in the patients with hearing disorders.
