Clinical significance of the interleukin 8 and interleukin receptor 1 axis in stomach neoplasms
10.3760/cma.j.issn.0254-9026.2018.04.017
- VernacularTitle:白细胞介素8及白细胞介素受体1信号轴在胃癌组织中的临床意义
- Author:
Liang YU
1
;
Guoqiang ZHOU
;
Shengyuan YU
;
Jian GUO
;
Dechun LI
Author Information
1. 215006 苏州大学附属第一医院普外科;常熟市第二人民医院普外科
- Keywords:
Gastric cancer;
CXCL8/CXCR1;
Tumor differentiation
- From:
Chinese Journal of Geriatrics
2018;37(4):427-430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore sensitive indicators for the initiation,development,and metastasis of gastric cancer and to provide objective evidence for the early diagnosis,treatment,and progression monitoring of gastric cancer.Methods A total of 108 patients with gastric cancer were enrolled in this study.The expression of interleukin receptor 1 (CXCR1)in samples from gastric cancer and adjacent tissues was detected by immunohistochemistry and patient clinical data were collected for correlation analysis.Logistic regression analysis of the 5-year survival rate of patients was conducted.Results The positive CXCR1 expression rate in gastric neoplasm tissues was significantly higher than that in adjacent tissues.Nevertheless,CXCR1 was correlated with tumor differentiation (P =0.017),TNM staging (P =0.006),and the existence of lymphatic metastasis (P =0.035).The overall survival rate (P =0.043) and recurrence-free survival rate (P=0.029) of patients with positive CXCR1 were lower than those of patients with negative CXCR1.Conclusions CXCR1 expression levels increase in gastric neoplasm tissues and are associated with tumor differentiation,TNM staging,and lymphatic metastasis.Positive CXCR1 is correlated with poor prognosis and has the potential to serve as one of clinical prognostic indicators.
