Application of three biomarkers in diagnosis of heart failure
10.3969/j.issn.1009-0126.2018.02.013
- VernacularTitle:三种生物学标志物在心力衰竭患者诊断中的应用
- Author:
Xiaofei HU
1
;
Shijia XU
;
Hong SUN
;
Shihua CHEN
Author Information
1. 314200,平湖市第一人民医院检验科
- Keywords:
heart failure;
natriuretic peptide,brain;
biological markers;
ROC curve
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(2):161-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the application of BNP,NT-proBNP and ST2 in diagnosis of heart failure (HF).Methods Ninety-seven HF patients admitted to our hospital served as a HF group and 61 HF-free patients served as a control group.The patients in HF group were further divided in to class Ⅱ group (n=32),class Ⅲ group (n=36) and class Ⅳ group (n=29) according to their cardiac function in NYHA classification.The serum ST2,BNP and NT-proBNP levels were measured and their value in diagnosis of HF was analyzed.Results The serum BNP,NT-proBNP and ST2 levels were significantly higher in HF group than in control group (396.0 ng/L vs 39.4 ng/L,P＜0.01;1825.0 ng/L vs 215.0 ng/L,P＜0.01;56.8 μg/L vs 25.4 μg/L,P＜0.01),which increased with the increasing cardiac function in NYHA classification (P＜0.01).The area under the ROC curve for BNP,NT-proBNP,ST2,combined NT-proBNP and ST2 was 0.874,0.891,0.842,0.905 respectively for the diagnosis of HF.Conclusion BNP,NT-proBNP and ST2,3 new biomarkers,can improve the diagnosis of HF.
