Correlation of intermedin 1-53 with hypertension and formation of carotid atherosclerotic plaques
10.3969/j.issn.1009-0126.2018.01.008
- VernacularTitle:中介素1-53与高血压颈动脉粥样硬化斑块形成之间的相关性
- Author:
Meiqun GUO
1
;
Minxia GE
;
Yayu XIE
;
Guangmin DUAN
Author Information
1. 311251,杭州市萧山区第三人民医院心内科
- Keywords:
adrenomedullin;
hypertension;
carotid artery diseases;
atherosclerosis;
ultrasonography;
calcitonin gene-related peptide
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between intermedin 1-53 (IMD 1-53) with hypertension and formation of carotid atheromatous plaques.Methods One hundred and thirty-eight patients with 1-2 degree hypertension admitted to our hospital for carotid ultrasonography were divided into atheromatous plaques group (n =98) and atheromatous plaques-free group (n=40) with 30 subjects undergoing physical examination served as a control group in this study.Their serum IMD 1-53 level,blood pressure,and carotid IMT were measured and compared.Results The SBP [(158.57±13.55)mm Hg and (145.16±14.54)mm Hg vs (125.24±10.64)mm Hg,1 mm Hg=0.133 kPa],DBP[(95.23±5.62)mm Hg and (87.15±4.72)mm Hg vs (80.31±4.62)mm Hg] and carotid IMT[(1.26±0.38)mm and (1.05±0.28)mm vs (0.87±0.38)mm] and serum IMD 1-53 level (7.20±1.62 ng/L vs 5.05±1.85 ng/L,P＜0.01) were significantly higher in atheromatous plaques group and atheromatous plaques-free group than in control group and in atheromatous plaques group than in atheromatous plaques-free group.Conclusion IMD 1-53 is involved in the formation of carotid atheromatous plaques and can resist or delay the formation of carotid atheromatous plaques.
