Immunotherapy may improve functional cure of chronic hepatitis B
10.3760/cma.j.issn.1674-2397.2018.04.003
- VernacularTitle:免疫治疗或可实现慢性乙型肝炎的功能性治愈
- Author:
Dan ZHU
1
;
Wen PAN
;
Jia LIU
;
Dongliang YANG
Author Information
1. 华中科技大学同济医学院附属协和医院感染病科
- Keywords:
Hepatitis B,chronic;
Immunity,innate;
Immunity,humoral;
Adaptive immunity;
Functional cure
- From:
Chinese Journal of Clinical Infectious Diseases
2018;11(4):261-268
- CountryChina
- Language:Chinese
-
Abstract:
Currently, clinical antiviral therapies for chronic hepatitis B virus (HBV) infection can efficiently control HBV replication.However, it remains difficult to achieve HBsAg clearance and sustains off-therapy, that is the functional cure of chronic hepatitis B ( CHB) in most of patients.Host immune responses play critical roles in HBV clearance and HBV infection control by activating innate and adaptive immune responses, resulting in improving the functional cure rate of patients with CHB.This article reviews the recent advances in immunology studies related to functional cure of CHB.
