Effect of microRNA-21 on the tumor biological behavior and research progress of molecular imaging and therapy targeting microRNA-21
10.3760/cma.j.issn.2095-2848.2018.05.015
- VernacularTitle:MicroRNA-21对肿瘤生物学行为的影响及其分子靶向成像与治疗的研究进展
- Author:
Yichao WANG
1
;
Changjiu ZHAO
Author Information
1. 150001,哈尔滨医科大学附属第四医院核医学科
- Keywords:
MicroRNAs;
Neoplasms;
Gene expression regulation;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(5):362-366
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) is a set of single-stranded RNA molecules with a length of 18-27 nucleotides,which can regulate the genesis and development of tumor and play the role of tumor suppres sor or oncogenic function by regulating its targeted gene-related signaling pathways.MicroRNA-21 (miR-21)is one of the early discovered miRNAs in human cells,and its expression is significantly elevated in a majority of cancers.The abnormal expression of miR-21 is closely associated with pathogenesis and progression of cancers.In this review,the progress of miR-21 in the occurrence,development,metastasis,treatment and molecular imaging of malignant tumors are summarized.
