Values of 18F-FDG uptake and thyroid transcription factor-1 expression to predict the mutations of epidermal growth factor receptor in lung adenocarcinoma
10.3760/cma.j.issn.2095-2848.2018.02.004
- VernacularTitle:18F-FDG摄取与甲状腺转录因子-1表达预测肺腺癌患者表皮生长因子受体突变的价值
- Author:
Chongyang DING
1
;
Tiannyu LI
;
Jin SUN
;
Zhe GUO
;
Xiao LI
Author Information
1. 210029,南京医科大学第一附属医院核医学科
- Keywords:
Lung neoplasms;
Adenocarcinoma;
Receptor,epidermal growth factor;
Thyroid nuclear factor 1;
Positron-emission tomography;
Tomography,X-ray computed;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(2):92-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective To validate the value of 18F-fluorodeoxyglucose (FDG) uptake on PET/CT and thyroid transcription factor-1 (TTF-1) expression to predict the epidermal growth factor receptor (EGFR)mutations in lung adenocarcinoma.Methods From May 2012 to May 2016,a total of 137 lung adenocarcinoma patients (89 males,48 females,age range 33-84 years) pathologically proved were reviewed retrospectively.EGFR mutation testing,TTF-1 expression and PET/CT scan were performed for all patients.x2test was used to assess the differences of EGFR mutation in different groups.Two-sample t test was used to compare the differences of maximum standardized uptake value (SUVmax) between EGFR mutation type and EGFR wild type,TTF-1 positive and negative expression.Multivariate logistic regression analysis was used to test the univariate models that yielded the best predictors of EGFR mutation receiver operating characteristic (ROC) curve analysis was performed to quantify the predictive value of those factors.Results EGFR mutation was identified in 53 patients,including 2 cases in exon 18,19 cases in exon 19,3 cases in exon 20 and 29 cases in exon 21.The high risk factors of EGFR mutation were female (x2=7.465,P=0.006),non-smoking (x2=7.193,P=0.007) and positive expression of TTF-1 (x2=9.104,P＜0.05).The SUVmax of EGFR mutation type was significantly lower than that of EGFR wild type (8.76±4.59 and 11.20±5.09;t =2.832,P =0.005).Multivariate analysis showed that the lower SUVmax (SUVmax ＜8.65) and positive expression of TTF-1 were the independent risk factors for EGFR mutation (P=0.032,P=0.018).The combined use of SUVmax and TrF-1 yielded a higher area under the ROC curve (area under curve=0.697),suggesting a good discrimination.Conclusion The combined evaluation of 18F-FDG uptake and expression of TTF-1 may be helpful in predicting EGFR mutation status in patients with lung adenocarcinoma,especially when the genetic testing is not available,and can provide meaningful clues for clinical treatment.
