Clinical effect of medical radiation protective ointment compared with trolamine cream to prevent acute radiation-induced skin injury in breast cancer patients undergoing radiotherapy after modified radical mastectomy
10.3760/cma.j.issn.1004-4221.2018.09.006
- VernacularTitle:医用射线防护剂对比三乙醇胺乳膏防治乳腺癌改良根治术后放疗皮肤损伤临床观察
- Author:
Xiaowen LAN
1
;
Xiao LIN
;
Haiyan HE
;
Jie CHEN
;
Xiaohua ZHU
;
Yuting TAN
;
Weiping XUE
;
Xiaobo HUANG
Author Information
1. 广东省恶性肿瘤表观遗传与基因调控重点实验室 中山大学孙逸仙纪念医院肿瘤放疗科
- Keywords:
Breast neoplasms/ intensity modulated radiation therapy;
Medical radiation protective ointment;
Acute radiation-induced skin injury
- From:
Chinese Journal of Radiation Oncology
2018;27(9):818-821
- CountryChina
- Language:Chinese
-
Abstract:
Objective To access the clinical effect of medical radiation protective ointment compared with trolamine cream to prevent acute radiation-induced skin injury in breast cancer patients undergoing radiotherapy after modified radical mastectomy. Methods Between February 2017 and February 2018,a total of 120 stage T1-4 N1-3 M0 eligible patients received intensity modulated radiation therapy were enrolled and matches into two groups:study group (60 cases) was administered medical radiation protective ointment from the first irradiation fraction,and control group (60 cases) received trolamine cream. When 3 grade reaction was observed,patients in control group start to administer medical radiation protective ointment until a month after radiation. Results The occurrence rate of acute breast dermal radiation reaction was 100％.Most patients in study group only underwent 1 grade radiation reaction (82％),while 2 and 3 grade radiation reaction (47％ and 13％) in control group were common ( P= 0. 000). Both pruritic degree and pain degree were higher in control group compared with study group (both P= 0. 000).In study group,the occurrence of 2 grade acute radiation-induced skin injury was obviously later than in control group with significant difference (P= 0. 000).Patients observed with 3 grade reaction relieved to certain reaction after administering medical radiation protective ointment. Conclusions Medical radiation protective ointment can effectively both alleviate and delay acute radiation-induced skin injury compared with trolamine cream. It also has therapeutic effect on 3 grade radiation reaction.
