Short-term efficacy of iodine-125 radioactive seed implantation therapy for hypoxic tumors
10.3760/cma.j.issn.1004-4221.2018.05.009
- VernacularTitle:125I放射性粒子植入治疗乏氧肿瘤近期疗效的临床研究
- Author:
Bao ZHENG
1
;
Chenghui SONG
;
Yun TENG
;
Jingbin SHI
;
Fuxiu YE
;
Hongwei LEI
;
Lijuan ZOU
;
Haichen ZHANG
Author Information
1. 116027,大连医科大学附属第二医院肿瘤放疗科
- Keywords:
Iodine-125 radioactive seed;
Hypoxic tumor;
Short-term efficacy
- From:
Chinese Journal of Radiation Oncology
2018;27(5):478-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the short-term efficacy of computed tomography (CT)-guided iodine-125(125I) radioactive seed implantation in the treatment of hypoxic tumors.Methods Twenty-two patients treated with 125I radioactive seed implantation in our department from 2014 to 2016 were divided into hypovascular tumor group (hypoxic group,n =12) and hypervascular tumor group (non-hypoxic group,n=10) based on the hemodynamics of solid tumor evaluated by color Doppler ultrasound.The enhanced CT images were loaded to the three-dimensional particle implantation planning system for preoperative planning.After 125I radioactive seed implantation,the D90 for target volume was verified to be 106-128 cGy.Treatment outcomes were evaluated according to the World Health Organization criteria at 1-3 months after surgery.Results In all the patients,the overall response rate was 82％ at 3 months after surgery.There were no significant differences in response (complete response + partial response) rates at 1,2,or 3 months after surgery between the hypoxic group and the non-hypoxic group (P=0.840,0.696,0.840).Conclusions In the treatment of solid malignant tumor,125I radioactive seed implantation can overcome the resistance of hypoxic tumor to radiotherapy in vitro and achieve satisfactory short-term efficacy.
