Radioprotective effects of resveratrol and its mechanism

VernacularTitle:白藜芦醇的放射防护作用及其机制研究进展
Author: Piaoyang GAO ¹ ; Liqing DU ; Qiang LIU
Author Information

1. 中国医学科学院北京协和医学院放射医学研究所天津市放射医学与分子核医学重点实验室
Keywords: Resveratrol; Ionizing radiation; Protection; Mechanism
From: Chinese Journal of Radiological Medicine and Protection 2018;38(5):390-394
CountryChina
Language:Chinese
Abstract: Resveratrol is a kind of natural active substance,which has strong antioxidant activity and radioprotective effect.A large number of tests have shown that resveratrol can attenuates radiation damage and play an important role in radiation protection,has a good application prospects.This paper reviews the radioprotective effects of resveratrol on the hematopoietic system,the immune system,the nervous system,the respiratory system,and other devices and their mechanisms of action.Including the HO1 signaling pathway,Nrf2 pathway and other antioxidant mechanisms and the activation of Sirt1 regulate the downstream signals,promote TyrRs into the nucleus to play the role of radioprotection.The prospect of application of resveratrol was also prospected.