Pregnancy outcome of patients ≥ 35 years old with diminished ovarian reserve treated with growth hormone
10.3760/cma.j.issn.1008-1372.2018.08.013
- VernacularTitle:生长激素用于≥35岁卵巢储备功能减退患者的妊娠结局观察
- Author:
Juanjuan ZHANG
1
;
Chaoyun WANG
;
Zhijun ZHANG
;
Chunlian ZHANG
Author Information
1. 442000,湖北省十堰市太和医院(湖北医药学院附属医院)生殖医学中心
- Keywords:
Primary ovarian insufficiency/DT;
Growth hormone/TU;
Pregnancy outcome
- From:
Journal of Chinese Physician
2018;20(8):1167-1170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application effect of growth hormone in patients ≥35 years old with diminished ovarian reserve (DOR),and to analyze pregnancy outcome.Methods A total of 120 cases with diminished ovarian reserve (≥35 years old) in our hospital were randomly divided into observation group and control group,each group of 60 cases.The control group was given conventional treatment,while the observation group added growth hormone.Changes of follicle stimulatng homone (FSH) and luteinizing hormone (LH),FSH/LH,serum estradiol (E2) level were compared between the two groups before and after treatment,along with the pregnancy outcome of two groups such as normal fertilization rate,excellent embryo rate,quantity of egg,cleavage rate,cycle cancellation rate.Results After treatment,the FSH and FSH/LH of the observation group were significantly lower than those of the control group,the serum E2 was significantly higher than that of the control group (P ＜ 0.05);the normal fertilization rate,cleavage rate and excellent embryo rate in the observation group were 53.96％,86.67％ and 35.38％ respectively,which were significantly higher than those of 33.58％,71.11％ and 15.63％ in the control group (P ＜ 0.05);the cycle cancellation rate of the observation group was 6.67％,which was significantly lower than that of 21.67％ in the control group (P ＜ 0.05);the biochemical pregnancy rate and clinical pregnancy rate of the observation group were 38.33％ and 28.33％,which were significantly higher than those of 20％ and 13.33％ in the control group (P ＜ O.05).Conclusions Diminished ovarian reserve in patients ≥35 years old with growth hormone therapy,can promote the improvement of ovarian function,the biochemical pregnancy rate and clinical pregnancy rate,it is worthy of clinical promotion.
