Rapid Determination of Iohexol Injection by a Refractive Index Method
10.3969/j.issn.1008-049X.2018.03.045
- VernacularTitle:折光率快速测定碘海醇注射液含量的方法研究
- Author:
Qian LIU
1
;
Wei JIN
;
Dan LI
;
Jian LE
;
Yongjian YANG
Author Information
1. 上海市食品药品检验所 上海201203
- Keywords:
Iohexol;
Refractive index;
Content determination;
Stoichiometric;
Rapid quantitative analysis
- From:
China Pharmacist
2018;21(3):521-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a stoichiometric relationship between iohexol injection and its refractive index. Methods: Ru-dolph J257 and Mettler Toledo RE40D were adopted to determine the refractive index of iohexol injection produced by different facto-ries. The relationship between the refractive index and the concentration of iohexol determined by potentiometric titration was described as C=2.828R-3.769. Results:The relative deviation of simulated content calculated by the stoichiometric and titration content was less than 2%. Little contribution by excipients could be ignored. Conclusion:The proposed method shows simplicity,rapidity and ac-curacy,which can be applied in the process control and the market supervision of iohexol.
