Efficacy of Rosuvastatin Combined with Danhong Injection in the Treatment of Unstable Angina Pectoris and Influence on Serum Levels of TNF-a, hs-CRP and IL-6
10.3969/j.issn.1008-049X.2018.01.026
- VernacularTitle:丹红注射液联合瑞舒伐他汀治疗不稳定型心绞痛患者的疗效及对血清TNF-a、hs-CRP和IL-6观察组
- Author:
Qian LU
1
;
Lewen LI
;
Zongwen HUANG
Author Information
1. 海南省干部疗养院 海口571100
- Keywords:
Danhong injection;
Rsuvastatin;
Unstable angina pectoris;
Inflammatory cytokines
- From:
China Pharmacist
2018;21(1):109-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the efficacy of rosuvastatin combined with Danhong injection in the treatment of unstable angina pectoris (UAP) and the influence on serum levels of TNF-α, hs-CRP and IL-6.Methods:Totally 72 patients with UAP were random-ly divided into the control group (n=36) and the observation group (n=36).All the patients received the conventional therapy .The control group was given rosuvastatin tablets ,10 mg,po, qd on the basis of the conventional therapy , while the research group was trea-ted with Danhong injection 30ml,ivd, qd on the basic of the control group .All the patients were treated for 2 weeks.The improvements of clinical symptoms and electrocardiogram , and the adverse reactions before and after the treatments were observed .The frequency of onset and duration before and after the treatment were recorded .The levels of blood lipid , TNF-α, hs-CRP and IL-6 before and after the treatment were detected .Results: The total effective rate of the observation group was 91.67％, which was significantly higher than that (72.22％) of the control group (P<0.05).The seizure frequency and duration of the research group were significantly low -er than those of the control group (P<0.05).After the treatment, the lipid indices such as TG, TC and LDL-C, and serum levels of TNF-α, hs-CRP and IL-6 of the two groups decreased significantly , while HDL-C significantly increased , and the differences were sta-tistically significant (P<0.05).The levels of TG, TC, LDL-C, TNF-a, hs-CRP and IL-6 were significantly lower in the observation group than those in the control group , while HDL-C was significantly higher than that in the control group (P<0.05).Conclusion:Danhong injection and rosuvastatin can effectively improve the clinical symptoms of UAP patients , reduce angina frequency and dura-tion, and decrease serum levels of TNF-a, hs-CRP and IL-6 to inhibit inflammation , which is safe and effective , and worthy of clinical application.
