Study on the Tissue Distribution of Asiaticoside in SD Rats
10.3969/j.issn.1008-049X.2018.01.005
- VernacularTitle:积雪草苷在SD大鼠体内组织分布的研究
- Author:
Lisha ZHU
1
;
Yingju LIU
;
Xinwei TAN
Author Information
1. 南充市中心医院· 川北医学院第二临床学院临床药学科 四川南充637000
- Keywords:
Asiaticoside;
Tissue distribution;
SD rats
- From:
China Pharmacist
2018;21(1):20-22,27
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the tissue distribution of asiaticoside in SD rats .Methods:The rats were injected by asiatico-side at the effective treatment dose of 42 mg kg -1 via tail vein.The rats sacrificed respectively at 5, 30 and 80 min after the injection and heart, liver, spleen, lung, kidney, stomach, intestine, brain, gonad and left thigh muscle were dissected immediately .The con-tent of asiaticoside in the tissues was determined by HPLC .Results:Asiaticoside widely distributed in SD rats , and the concentration in heart was the highest followed by liver , brain, lung, spleen and kidney .The contents in the other tissues were relatively low .Con-clusion:The method is convenient , sensitive and accurate , and can be used for the content determination of asiaticoside the tissues of SD rats.
