Dissolution Comparison of Compound Fructus Forsythiae,Paracetamol and Chlorphenamine Maleate Cap-sules from Different Manufacturers
- VernacularTitle:不同厂家复方银翘氨敏胶囊溶出度比较
- Author:
Yan ZHANG
1
;
Shuqing LUO
;
Zheng ZHOU
;
Lin CAO
Author Information
1. 宁波市药品检验所 浙江宁波315048
- Keywords:
Compound fructus forsythiae;
paracetamol and chlorphenamine maleate capsules;
Paracetamol;
Dissolution;
Dissolution curve;
Similar factor
- From:
China Pharmacist
2017;20(11):2067-2071
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the dissolution of compound fructus forsythiae, paracetamol and chlorphenamine maleate cap-sules from different manufacturers.Methods: The dissolution test was carried out by a basket method in 900 ml dissolution medium with the rotating speed at 100 r·min-1. The dissolution profiles of compound fructus forsythiae,paracetamol and chlorphenamine mal-eate capsules from different manufacturers in four dissolution media including hydrochloric acid solution, pH 4.5 acetate buffer solu-tion,water and pH 6.8 phosphate buffer solution were determined,and the dissolution curves were compared by a similar factor meth-od. Results:The cumulative dissolution of compound fructus forsythiae,paracetamol and chlorphenamine maleate capsules from seven manufacturers was all over 70% in 30 min in hydrochloric acid solution,while failed to dissolve well in pH 4.5 acetate buffer solution, water and pH 6.8 phosphate buffer solution. All the dissolution curves in the 4 dissolution media were different among the batches. Conclusion:The quality of compound fructus forsythiae,paracetamol and chlorphenamine maleate capsules from various manufacturers is much different. Promising dissolution should be guaranteed,at the same time,the stability needs to be improved.
