Curative Effect of Tegafur Gimeracil Oteracil Potassium Capsules Combined with Oxaliplatin in the Treat-ment of Advanced Gastric Cancer and Influence on MMP-9 Expression in Cancer Tissue
- VernacularTitle:替吉奥联合奥沙利铂治疗进展期胃癌的疗效及对癌组织中MMP-9表达的影响
- Author:
Jing ZHANG
1
;
Zijiao ZHOU
;
Shuhui YAO
;
Junquan YANG
;
Yaju FAN
;
Yuping ZHU
Author Information
1. 唐山市人民医院 河北唐山063000
- Keywords:
Gastric cancer;
Tegafur gimeracil oteracil potassium capsules;
Neoadjuvant chemotherapy;
Matrix metalloproteinase-9
- From:
China Pharmacist
2017;20(11):2015-2017
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of Tegafur gimeracil oteracil potassium(Gio) capsules combined with oxaliplatin in the treatment of advanced gastric cancer,and explore its effect on matrix metalloproteinase-9 (MMP-9) expression in cancer tissues. Methods: Totally 120 patients with advanced gastric cancer were randomly divided into the observation group and the control group, and both groups were treated with neoadjuvant chemotherapy for 3 cycles as follows:the observation group was given Gio capsules and oxaliplatin,and the control group was given 5-fluorouracil combined with oxaliplatin. The short term efficacy,adverse reactions and ex-pression of MMP-9 in cancer tissue before and after the chemotherapy were observed in the two groups. Results:After the treatment, the objective response rate in the two groups had no significant difference(P>0.05);the clinical benefit rate of the observation group was significantly higher than that of the control group(P<0.05);the incidence of severe bone marrow suppression and liver and kid-ney dysfunction in the observation group was significantly lower than that in the control group(P<0.05);after the treatment,the pos-itive expression of MMP-9 in the observation group was significantly lower than that in the control group(P<0.05). Conclusion:Gio capsules combined with oxaliplatin can improve the clinical benefit rate of the patients with advanced gastric cancer,and effectively re-duce the expression of MMP-9 in cancer tissue.
