Effects of Jiannao Yishou Capsule on Learning and Capillary Structure of Hippocampal in Alzheimer's Dis-ease Mice
- VernacularTitle:健脑益寿胶囊对阿尔茨海默病小鼠学习记忆和海马毛细血管结构的影响
- Author:
Hui SU
1
;
Hongxin FEI
;
Yingbo ZHANG
;
Yunming SU
Author Information
1. 黑龙江中医药大学药学院 哈尔滨150040
- Keywords:
Jiannao Yishou capsule;
Alzheimer's disease;
Learning and memory
- From:
China Pharmacist
2017;20(11):1972-1975
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effects of Jiannao Yishou capsule(JYC) on hippocampal in Alzheimer's dis-ease (AD) mice. Methods:Male mice were randomly divided into normal control group,model control group,positive control group (donepezil hydrochloride tablets,0.001 g·kg-1),JYC high-dose (3.744 g·kg-1) and low-dose (0.936 g·kg-1) group. Morris water maze was used to test the learning and memory ability of mice. The hippocampal capillary structure was observed by light micros-copy and electron microscopy and the level of hippocampal Aβ was measured by enzyme-linked immunoassay.Results:Compared with the normal control group,the model control group learning and memory significantly reduced,and capillary endothelial cell mitochon-drial degeneration,nuclear condensation,broadening of the perinuclear space,overlapping,Aβ in hippocampal of AD mice were sig-nificantly reduced (P<0.05). Compared with the model control group,the JYC high-dose group learning and memory of mice im-proved significantly (P<0.05),and hippocampal capillary endothelial cell morphology improved significantly,and Aβ in Hippocam-pal of AD mice were significantly reduced(P<0.05). Conclusion:JYC can maintain normal morphological structure of hippocampus capillaries of AD mice,decrease Aβ responses and Improve learning and memory. JYC has protective effects on hippocampal tissues in AD mice.
