Review research on tumor prevention of probiotics
10.3969/j.issn.1001-1978.2018.03.004
- VernacularTitle:益生菌预防肿瘤作用研究进展
- Author:
Ai-Yun WANG
1
;
Ying SHEN
;
Jin-Qiu ZHONG
;
Ting-Ting ZHANG
;
Wen-Xing CHEN
;
Zhi-Guang SUN
;
Yin LU
Author Information
1. 南京中医药大学江苏省中药药效与安全性评价重点实验室 江苏南京 210023;南京中医药大学江苏省中医药防治肿瘤协同创新中心 江苏南京 210023
- Keywords:
microbiota;
probiotics;
intestinal flora;
tumor pre-vention;
mechanism;
immunoregulation
- From:
Chinese Pharmacological Bulletin
2018;34(3):312-315
- CountryChina
- Language:Chinese
-
Abstract:
Recently,research on microbes has been explored ex-plosively. Microbial-related studies have become the forefront of anti-cancer research. A large number of microorganisms are uni-versal in the viscera, skin, nose, mouth and reproductive sys-tem. Probiotics is a kind of microorganisms beneficial to human health. Although most studies have proven the tumor-promoting effects of bacterial flora,antitumor effects of probiotics have also been observed. Studies have confirmed that probiotics can pre-vent the onset of early stage colon cancer as well as non-colorec-tal cancer mainly via several mechanisms,such as adjustment of intestinal flora,regulation of immune response,anti-inflammato-inactivation of metabolic carcinogen, antioxidant and induction of tumor cell apoptosis. However,the specific underlying molecular mechanism still needs to be further studied. The latest studies on human have shown that intestinal microbiota combining with diet can alter the risk of special colorectal cancer. As a cancer chemoprevention strategy, more pre-clinical and clinical research are in need for the study of the effects of probiotics on cancer prevention and treatment.
