Pathogenesis of diabetic cognitive dysfunction and intervention by traditional Chinese medicine
10.3969/j.issn.1001-1978.2018.03.002
- VernacularTitle:糖尿病认知功能障碍的机制及中药干预研究进展
- Author:
Ya-Dong ZHAI
1
;
Gui-Bo SUN
;
Yong-Mei WU
;
Tian-Yuan YE
;
Xiang-Bao MENG
;
Xiao-Bo SUN
Author Information
1. 中国医学科学院北京协和医学院药用植物研究所
- Keywords:
diabetes mellitus;
cognitive dysfunction;
pathogen-esis;
metabolic abnormalities;
traditional Chinese medicine;
treatment and prevention
- From:
Chinese Pharmacological Bulletin
2018;34(3):303-308
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cognitive dysfunction (DCD) is a common chronic complication of diabetes mellitus with sophisticated path-ogenesis which has not yet been fully elucidated. In this review paper, the mechanisms of metabolic abnormalities, insulin re-sistance,endoplasmic reticulum stress,neuronal calcium dysho-meostasis, in ammation, blood brain barrier impairment, and mitochondrial injury associated with DCD are reviewed. In addi-tion,the prevention and treatment of DCD by traditional Chinese medicines (TCMs) and the effective compounds are comprehen-sively summarized, in order to provide an updated overview on the DCD pathogenesis,as well as the scientific evidence under-pinning the use of TCM interventions for the treatment and pre-vention of DCD.
