Study on the Mechanism of Artemisia capillaries Based on Systems Pharmacology
10.6039/j.issn.1001-0408.2018.10.05
- VernacularTitle:基于系统药理学的茵陈作用机制研究
- Author:
Guoming CHEN
1
;
Shunli TANG
;
Zijun KUANG
;
Yan HUANG
;
Jinlong ZHAO
;
Jingwen YU
;
Ziyin CHEN
;
Hongrong LIN
;
Chuyao HUANG
;
Hua XU
Author Information
1. 广州中医药大学第一临床医学院
- Keywords:
Systems pharmacology;
Artemisia capillaries;
Effective compound;
Target protein;
Signaling pathway;
Pharmacological effect
- From:
China Pharmacy
2018;29(10):1312-1319
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the possible mechanism of Artemisia capillaries,and to provide reference for further development and utilization of it. METHODS:The effective components and related target protein of A. capillaries were screened by Traditional Chinese Medicine Systems Pharmacology (TCMSP) analysis platform database. The effective compound-target protein visual network of A. capillaries was established by using Cytoscape 3.5.1 software,topology analysis was also performed. The protein-protein interaction (PPI) network was constructed and analyzed by STRING database. KEGG pathway enrichment of target protein coding gene was analyzed by DAVID bioinformatics resource database. RESULTS:A total of 13 kinds of effective compounds,189 target proteins and 34 enrichment pathways were selected. Quercetin,β-glutamol,isorhamnetin and artepillin C were main effective compounds. Prostaglandin G/H sythase 2(PTGS 2),heat shock protein 90(HSP 90),dipeptidyl peptidase Ⅳ, protein kinase A catalytic subunit Cα were main target proteins. Transcription factor AP-1 and cell tumor antigen p53 played a key role in PPI network. The target protein coding gene was rich in TNF-α signaling pathway,HIF-1 signaling pathway,Toll-like receptor signaling pathway,PI3K/Akt signaling pathway,T cell receptor signaling pathway,thyroid hormone signaling pathway, apoptotic signaling pathway,etc. CONCLUSIONS:Quercetin,β-glutamol and isorhamnetin of A. capillaries play an effect on PTGS2,HSP90,transcription factor AP-1 and other target proteins through TNF-α signaling pathway,HIF-1 signaling pathway and PI3K/Akt signaling pathway,so as to play anti-inflammatory and antitumor effect.
