Process in targeted contrast agents for cancer imaging
10.11665/j.issn.1000-5048.20170602
- VernacularTitle:肿瘤靶向性造影剂的研究进展
- Author:
Letian WANG
1
;
Jinglin WANG
;
Hongwu LIU
;
Ying GE
;
Yuyan LI
;
Qingxiang XU
Author Information
1. 中国药科大学药学院药物化学教研室江苏省药物分子设计与成药性优化重点实验室
- Keywords:
medical imaging;
tumor targeting;
contrast agents;
advances
- From:
Journal of China Pharmaceutical University
2017;48(6):635-645
- CountryChina
- Language:Chinese
-
Abstract:
The application of medical imaging technology is playing an important role in diagnosis and treatment of cancer.In clinic,the most commonly used imaging technology to detect cancers are X-ray computed tomo graphy,nuclide imaging,magnetic resonance imaging and near-infrared fluorescence imaging.Contrast agents could enhance imaging signals and increase the sensitivity and accuracy of cancer detection.Neverthness,most of clinically used contrast agents have problems such as short retention time and tumor targeting insufficient,which is not favorable to cancer detecting.So it is of great significance to develop tumor targeting contrast agents.Currently,targeting strategies are divided into three types:passive targeting,active targeting and activatable targeting.In this review,we conclude the recent progress and applications of tumor targeting contrast agents of different imaging modilities.Besides,the future development of tumor targeting contrast agents is also prospected.
