Research status of rhoptry protein of Toxoplasma gondii and its nucleic acid vaccine
10.16250/j.32.1374.2017162
- VernacularTitle:弓形虫棒状体蛋白及其核酸疫苗研究现状
- Author:
Rong MA
1
;
Hui SUN
;
Ge YAN
;
Qing-Kuan WEI
Author Information
1. 济南大学-山东省医学科学院医学与生命科学学院 济南250000;山东省寄生虫病防治研究所 济宁272033
- Keywords:
Toxoplasma gondii;
Rhoptry protein(ROP);
Nucleic acid vaccine;
Immunoprotection
- From:
Chinese Journal of Schistosomiasis Control
2018;30(1):94-98
- CountryChina
- Language:Chinese
-
Abstract:
At present,there are no ideal drugs and measures in the treatment and prevention of toxoplasmosis.The develop-ment of safe,convenient,and strong protective nucleic acid vaccine is an important strategy for prevention and control of toxo-plasmosis.The rhoptry protein(ROP)is a large class of proteins secreted by Toxoplasma gondii.ROPs play an important role in the invasion of host cells,the formation of parsitophorous vacuole(PV)and the regulation of proliferation by T.gondii.Thus, ROPs become the most promising candidates of vaccine.In this paper,we summarize the important members of the ROPs,the expression vector and the immunogenicity and immunoprotection of the nucleic acid vaccine in animal experiments.
