The correlation between circRNA expression level in peripheral blood and severity of cognitive dys-function of major depressive disorder
10.3760/cma.j.issn.1674-6554.2018.11.009
- VernacularTitle:抑郁症患者外周血circRNA表达水平与认知功能障碍的相关性研究
- Author:
Lingming KONG
1
;
Wei NIU
;
Xiaoli ZHU
;
Mingjun HE
;
Gaofeng YAO
;
Shengdong CHEN
;
Liyi ZHANG
Author Information
1. 解放军第904医院全军心理疾病防治中心
- Keywords:
Cognitive dysfunction;
circRNA;
Differentiated expression;
Major depresssive disorder
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(11):1001-1005
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of circRNA expression level in peripheral blood and severity of cognitive dysfunction of major depressive disorder(MDD). Methods Gene chip technique was performed in peripheral blood mononuclear specimen from 5 MDD patients and 5 controls respectively for confirming circRNAs of aberrant expression,and further verification was done in a larger sample of 100 MDD patients by real-time fluorescence quantitative PCR,and all of MDD patients and controls were assessed by Montreal Cognitive Assessment-Beijing Version ( MoCA). Results Compared with the controls, scores of visuospatial & executive function, attention & computation, abstraction, delayed memory were significantly lower in MDD patients (t=-3. 89--1. 91,P<0. 05). Expression level of circRNA_002143 had negative cor-relation with attention & computation(r=-0. 645,P<0. 01 ). In MDD patients,expression levels of circRNA_103636,circRNA_100679,circRNA_104953 were positively correlated with visuospatial & executive func-tion,attention & computation,abstraction,delayed memory(r=0. 462-0. 589,P<0. 05 or 0. 01). Expression level of circRNA_100679,circRNA_104953 had predictive effect on visuospatial & executive function(t=9. 49,9. 31,P<0. 01) and accounted for 29. 0% of variances and circRNA_104953 had predictive effect on abstraction(t=8. 22,P=0. 009) and accounted for 28. 5% of variances. ROC analysis suggested expression levels of circRNA_103636,circRNA_100679,circRNA_104953 had neutral predictive efficacy on cognitive function(0. 7
