Effects of paliperidone on MK-801-induced hyperactivity and disruption prepulse inhibition in rats
10.3969/j.issn.1002-0152.2017.12.004
- VernacularTitle:帕利哌酮对地卓西平马来酸盐引起大鼠自发活动增加及感觉门控功能异常的作用
- Author:
Yaxin SUN
1
;
Jitao LI
;
Yunai SU
;
Tianmei SI
Author Information
1. 北京大学第六医院
- Keywords:
Schizophrenia;
Paliperidone;
Dizocilpine;
Locomotor activity;
Prepulse inhibition
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(12):721-727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of risperidone and its active metabolite, paliperidone (9-hydroxyrisperidone), on hyperactivity and deficient sensorimotor gating induced by MK-801 in rats. Methods Adult male Sprague-Dawley (SD) rats (n=96) were used in this study. The effects of risperidone (0.1 mg/kg) and paliperidone (0.05, 0.10 and 0.20 mg/kg) on MK-801-induced (0.40 mg/kg) hyperactivity were examined in 48 rats with with 8 animals per group.The effects of risperidone(0.5 mg/kg)and paliperidone(0.10,0.50,1.00 mg/kg)on MK-801-induced (0.25 mg/kg) deficit in prepulse inhibition (PPI) were examined in 48 rats with 8~10 animals per group. Results Risperidone (0.10 mg/kg) and paliperidone (0.05 mg/kg) diminished the MK-801-induced hyperactivity (P<0.05). But paliperidone (0.10, 0.20 mg/kg) group did not affect locomotor activity compared to the control group. Risperidone (0.10 mg/kg) and different doses of paliperidone (0.10, 0.50, 1.00 mg/kg) enhanced the PPI baseline in rats. However, only risperidone (0.10 mg/kg), but not paliperidone restored the MK-801-induced deficits in PPI. Conclusion Risperidone and paliperidone have different pharmacological actions on MK-801-induced hyperactivity and deficits in prepulse inhibition in rats, suggesting that pharmacological actions of paliperidone are different from those of risperidone, although paliperidone is the active metabolite of risperidone.
