Death caused by ST19 Klebsiella oxytoca with wcaG virulence gene in leukemic patient
10.3969/j.issn.1002-2694.2017.08.018
- VernacularTitle:携带wcaG毒力基因ST19产酸克雷伯菌致白血病患者死亡的分析
- Author:
Hui DING
1
;
Long-Hua HU
;
Qiao-Shi ZHONG
;
Ya-Ping HANG
;
Yan-Ling LIU
;
Feng YU
;
Yan-Hui CHEN
;
Xiao-Yan HU
;
Li-Ming ZHANG
;
Bai-Ling ZHANG
;
Nan ZHANG
;
Xiao-Zhong WANG
Author Information
1. 南昌大学第二附属医院检验科
- Keywords:
Klebsiella oxytoca;
virulence;
leukemic;
mucous;
multilocus sequence typing (MLST)
- From:
Chinese Journal of Zoonoses
2017;33(8):753-756
- CountryChina
- Language:Chinese
-
Abstract:
We investigated the cause of a leukemia patient induced by infect in a strain of Klebsiella oxytoca with hypermucoviscosity (HMV) phenotype.Identification and drug susceptibility of the isolate were carried out with VITEK-2 compact system.HMV phenotype was detected by string-test.The major high virulence capsular serotypes (K1,K2,K5,K20,K54 and K57) and virulence factors (rmpA,wcaG,allS,kfu,aerobactin,fimH,uge,wabG and cf29a) were detected by polymerase chain reaction and DNA sequencing.Molecular typing was performed by multilocus sequence typing (MLST).Results showed that the isolates of blood and lung tissue were Klebsiella oxytoca belonged to ST 19,which were sensitive to the antibiotics used in test,expressing the HMV phenotype.The virulence gene wcaG was found,while other virulence genes and the major high virulence capsular serotypes were negative.It indicates that ST19 Klebsiella oxytoca with wcaG virulence gene is the main reason causing leukemic patient death.
