IL-17D regulates recruitment of lung NK cells and promotion of Astragalus membranaceus
10.3969/j.issn.1000-484X.2018.03.015
- VernacularTitle:IL-17D调控肺脏NK细胞募集及黄芪的促进作用
- Author:
Hong-Yun LAN
1
;
Xiao-Dan ZHENG
;
Yu-Qi GUO
;
Lei AN
;
Xiao-Yan SUN
;
Yan-Min LÜ
;
Li WANG
;
Cheng-Fang YAO
Author Information
1. 济南大学 山东省医学科学院医学与生命科学学院
- Keywords:
IL-17D;
NK cells;
Lung;
Astragalus;
Lung cancer
- From:
Chinese Journal of Immunology
2018;34(3):393-397
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of IL-17D to regulate the recruitment of lung NK cells and the effects of Astragalus membranaceus on IL-17D.Methods:The lung metastasis of tumor model was established by injecting B16 melanoma cells through caudal vein.After being treated with IL-17D or Astragalus membranaceus respectively,the expression of IL-17D and NK cells in lung was detected by flow cytometry and RT-PCR.Results:The production of IL-17D and the content of NK cells in the lung tumor me-tastasis model were dramatically decreased.After treatment with IL-17D,the content of NK cells in lung was significantly increased and the lung tumor foci were decreased.Along with up-regulated recruitments of NK cells,CXCL9 and IL-15,which support NK cell recruitments and maintain survival,were significantly increased.Astragalus inhibited lung tumor developments in lung by increasing the IL-17D expression and up-regulated the lung NK cell content.Conclusion: IL-17D can regulate the lung recruitment of NK cells.Astragalus mongholicus can enhance the capacity of NK cell recruitment and promote anti-tumor immune effects by up-regulating the expression of IL-17D.
