Advances in the study of long non-coding RNA and osteoarthrosis
10.3760/cma.j.issn.2095-4255.2018.11.018
- VernacularTitle:长链非编码RNA与骨关节病的研究进展
- Author:
Xinhua SHAO
1
;
Fuyuan LI
;
Ning ZOU
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心中心实验室
- Keywords:
Osteoarthritis;
lncRNA;
Regulatory mechanism
- From:
Chinese Journal of Endemiology
2018;37(11):929-932
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthrosis is a disease characterized by degeneration of articular cartilage,inflammation of the synovial membrane in the joint,and changes of the surrounding joints and subchondral bone.The main pathologic changes of osteoarthrosis are chondrocytes reduction and extracellular matrix degradation,which then affect the synovial membrane and articular cartilage bone plate accompanied by osteophyte formation,lead to a series of joint symptoms and signs.Modern medical research shows that long non-coding RNA (lncRNA) plays a certain role in the pathogenesis and development of osteoarthrosis.In this paper,the advances in the study of lncRNA and osteoarthrosis are reviewed.
