Association of arsenic exposure through drinking water and tumor:a meta-analysis
10.3760/cma.j.issn.2095-4255.2018.02.017
- VernacularTitle:饮水砷暴露与肿瘤相关性的Meta分析
- Author:
Qing ZHOU
1
;
Shuhua XI
Author Information
1. 中国医科大学公共卫生学院地球化学性疾病研究室
- Keywords:
Arsenic;
Drinking water;
Tumor;
Meta-analysis
- From:
Chinese Journal of Endemiology
2018;37(2):155-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the relationship between arsenic exposure through drinking water and human cancer risk.Methods China National Knowledge Infrastructure(CNKI), VIP Database, WanFang Data,China Biology Medicine Disc(CBM),PubMed,Embase and Cochrane Library were searched through computer to find out the relationship between arsenic exposure and tumorigenesis.The search period was from January 1,1997 to January 1,2017.Meta-analysis was performed using RevMan 5.3.The heterogeneity of the literatures that met the inclusion criteria was examined,and analysis was performed by using fixed effect model or random effect model. OR and 95%CI were calculated, the publication bias was evaluated by inverted funnel plot, and sensitivity analysis was performed. Results Totally 14 literatures entered into this study, 13 927 people in arsenic exposure group, 5 720 people in control group. The meta-analysis showed that, 14 literatures were homogeneous through the heterogeneity test, and was analyzed in the fixed effect model with OR (95 % CI) = 1.20 (1.09, 1.33),which suggested that the risk of cancer in the arsenic exposure group was 1.20 times higher than that in control group. Inverted funnel plot was basically symmetrical,literatures publication bias was small;the result was more reliable by sensitivity analysis.Conclusion Arsenic exposure through drinking water may be a risk factor of tumor.
