Research Progress in Multiple Target Action Mechanisms of Myocardium of Exogenous Phosphocreatine
10.3870/j.issn.1004-0781.2018.02.006
- VernacularTitle:外源性磷酸肌酸 心肌保护多靶作用机制的研究进展
- Author:
Guozhu HAN
1
;
Zeyao TANG
Author Information
1. 大连医科大学药学院
- Keywords:
Phosphocreatine,exogenous;
Myocardium;
Membrane;
Mitochondria
- From:
Herald of Medicine
2018;37(2):165-171
- CountryChina
- Language:Chinese
-
Abstract:
Phosphocreatine ( PCr), a natural high energy phosphate, plays a pivotal role in maintaining energy homeostasis of the body. Exogenous PCr has been developed as a cardio-protective drug and extensively used in treatment of cardiovascular diseases.PCr has special chemical structure,which confers much bioinformation on it,and becomes a multitarget-directed drug.Since the 21st century,with rapid development of molecular biology,the multiple target action mechanisms of PCr have continually gained elucidation,including energy-related and non-energy-related mechanisms,intracellular and extracellular mechanisms,which are leading to its extensive clinical applications in cardiovascular diseases.Based on author' s research and published literatures,this article reviews the research progress in multiple target action mechanisms of PCr,including energy supply,membrane stabilization, anti-platelet aggregation, electrophysiology, enzyme inhibition and protection of mitochondria, antiapoptotic effect,etc.
