Expression and clinical significance of T cell immunoglobulin and mucin domain-3 and programmed death-1 on T lymphocytes of peripheral blood in breast invasive ductal carcinoma patients
10.3760/cma.j.issn.1673-4904.2018.04.009
- VernacularTitle:T细胞免疫球蛋白及黏蛋白结构域分子3、程序性细胞死亡蛋白1在乳腺浸润性导管癌患者外周血中的表达及意义
- Author:
Qi ZHOU
1
;
Ximing ZHONG
;
Yu FAN
Author Information
1. 江苏大学附属人民医院肿瘤科
- Keywords:
Breast neoplasms;
T cell immunoglobulin and mucin domain-3;
Programmed death-1
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(4):321-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of T cell immunoglobulin and mucin domain-3 (Tim-3)and programmed death-1(PD-1) on T lymphocytes in breast invasive ductal carcinoma patients and their clinical significance. Methods All peripheral blood of 40 breast cancer patients and 10 healthy people was obtained.The expressions of TIM-1 and PD-1 on T lymphocytes were analyzed by flow cytometry, and the relationship between them and clinical pathological features were analyzed. Results The frequency of TIM-3 cells among T lymphocytes in breast cancer patients peripheral blood was significantly higher than that in healthy people: (2.01 ± 0.62)% vs. (0.26 ± 0.08)%, P=0.03. The frequency of TIM-3 cells among T lymphocytes in peripheral blood of low differentiated breast cancer patients was also higher than that in middle- high differentiated patients: (4.45 ± 1.22)% vs. (1.02 ± 0.27)%,P=0.00.The number of PD-1 and Tim-3 cells showed a significant positive correlation (r=0.47,P=0.02). Conclusions TIM-3 cells may suppress immune to tumor cells and accelerate the development of breast cancer.
