Influence of nicorandil on levels of hsCRP ,sCD40L and therapeutic effect of nicorandil in patients with microvascular angina pectoris
10.3969/j.issn.1008-0074.2018.03.16
- VernacularTitle:尼可地尔对微血管性心绞痛患者hsCRP、sCD40L水平的影响及临床疗效
- Author:
Bin CHEN
1
;
Hua LIU
;
Yong-Jun ZHANG
;
Zhi-Hui MA
;
Jian-Ping TAO
;
Yu HU
;
Jin-Mei ZENG
;
Xing-De WANG
;
Zhong CHEN
Author Information
1. 上海市第六人民医院心内科
- Keywords:
Microvacular angina;
C-reactive protein;
CD40 ligand;
Nicorandil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(3):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore influence of nicorandil on plasma levels of high sensitive C reactive protein (hsCRP) and soluble T cell CD40 ligand (sCD40L) and therapeutic effect of nicorandil in patients with microvascular angina pectoris .Methods :A total of 102 patients with microvascular angina pectoris were enrolled ,randomly and equally divided into routine treatment group (received routine comprehensive treatment ) and nicorandil group (received nic-orandil based on routine comprehensive treatment ,5mg ,3 times/d) ,both groups were treated for eight weeks . Plasma levels of hsCRP and sCD40L were measured and compared between two groups before and eight weeks after treatment ,and therapeutic effect was compared between two groups .Results : Compared with before treatment there were significant reductions in plasma levels of hsCRP and sCD 40L in both groups after eight weeks ;compared with routine treatment group after treatment ,there were significant reductions in plasma levels of hsCRP [ (2.63 ± 0.25) mg/L vs.(1.80 ± 0.28) mg/L] and sCD40L [ (71.88 ± 3.71) pg/ml vs .(55.25 ± 2.47) pg/ml] in nicorandil group , P＝0. 001 all.Total effective rate of nicorandil group was significantly higher than that of routine treatment group (78.43% vs.56.86%,P＝0.02).Conclusion :Nicorandil can significantly rise clinical effect ,reduce plasma levels of hsCRP and sCD40L in patients with microvascular angina pectoris .
