Treating glioma with umbilical cord mesenchymal stem cells: mechanism of action, safety and future application
10.3969/j.issn.2095-4344.0530
- VernacularTitle:脐带间充质干细胞治疗脑胶质瘤:作用机制、安全性和未来应用前景
- Author:
Xin-Kui ZHOU
1
;
Shan-Shan MA
;
Teng-Fei LIU
;
Jian-Kang ZHOU
;
Qu XING
;
Tuan-Jie HUANG
;
Ya-Ping WANG
;
Bo YANG
;
Fang-Xia GUAN
Author Information
1. 郑州大学生命科学学院
- From:
Chinese Journal of Tissue Engineering Research
2018;22(17):2740-2746
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Umbilical cord mesenchymal stem cells (UC-MSCs) are a group of cells that have self-renewal, highly proliferative and multidrug differentiation potential. The properties of UC-MSCs and their tumor tropism make them an ideal tool for glioma cell therapy. These cells can act by paracrine or as a delivery system for genes and drugs. It has been demonstrated that UC-MSCs can inhibit the growth of glioma and improve the survival after transplantation into the brain. OBJECTIVE: To summarize the molecular mechanisms and safety of UC-MSCs in the treatment of glioma and to provide a useful reference for further research. METHODS: We searched the PubMed and CNKI databases from 2000 to 2017 with the English terms of "glioma; umbilical cord mesenchymal stem cells" and the Chinese terms of "glioma; umbilical cord mesenchymal stem cells; safety; molecular mechanism". Based on the inclusion and exclusion criteria, 55 articles were finally reserved for review. RESULTS AND CONCLUSION: UC-MSCs have obvious effect on treating glioma. These cells can treat glioma through homing mechanism and paracrine mechanism as gene carrier and co-culture. Moreover, UC-MSCs have certain safety in the treatment of glioma.
