Evaluation of renal function in congenital spinal deformities patients with urinary malformations
10.7652/jdyxb201802018
- VernacularTitle:先天性脊柱畸形合并泌尿系畸形患者的肾功能评估
- Author:
Zheng-Chao GAO
1
;
Jian-Tao LIU
;
Bin-Bin NIU
;
Yu-Huan LI
;
Hui LIANG
;
Hao-Peng LI
;
Xi-Jing HE
Author Information
1. 西安交通大学第二附属医院骨科
- Keywords:
congenital spinal deformities;
congenital urinary malformation;
early renal function impairment
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(2):245-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate renal function in congenital spinal deformities patients with urinary malformations.Methods We prospectively enrolled patients diagnosed with congenital spinal deformities combined with urinary malformation as well as age- and weight-matched healthy individuals and divided them into three groups:renal malformations group,urinary tract malformations group,and healthy control group.Serum creatinine,blood urea,blood uric acid,serum cystatin C,and estimate glomerular filtration rate(eGFR)level were used to evaluate general renal function.Urinary microalbumin(mALB),urinary alpha-1-microglobulin(α1-MG), beta-2-microglobulin(β2-MG),and N-acetyl-beta-D-glucosaminidase(NAG)level were determined to evaluate early renal function.Results We enrolled totally 16 patients with renal malformations,14 patients with urinary tract malformations group,and 20 healthy individuals as controls.The concentration of serum creatinine,blood urea, blood uric acid,serum cystatin C,and the value of eGFR in the three groups were within normal reference values, with no significant difference(P＞0.05).There were significant differences in the urinary levels of mALB,α1-MG and NAG in the three groups(P＜0.05),but not for the concentration of β2-MG(P＞0.05).Urinary levels of mALB and NAG were significantly higher in renal malformations group than in urinary tract malformations group (P＜0.05),but not for the concentration of α1-MG(P＞ 0.05).Conclusion Early renal function impairment occurs in congenital spinal deformities children with urinary malformation.Moreover,it appears more severe in patients with renal malformations than in those with urinary tract malformations.
