Correlation of serum bile acid concentration with inflammatory cytokines and ventricular remodel in elderly patients with chronic heart failure
10.11958/20170972
- VernacularTitle:老年慢性心衰患者血清胆汁酸水平与炎症因子及心室重构的关系
- Author:
Rui SHAN
1
;
Pei-Gen YANG
Author Information
1. 天津市武清区人民医院心内科
- Keywords:
heart failure;
ventricular remodeling;
interleukin-6;
tumor necrosis factor-alpha;
bile acid;
inflammation
- From:
Tianjin Medical Journal
2018;46(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of serum total bile acid (BA) with inflammatory cytokines and ventricular remodeling in elderly patients with chronic heart failure (CHF). Methods A total of 82 patients with CHF were divided into mild group (NYHA grade Ⅱ, n=47) and moderate group (NYHA grade Ⅲ, n=35), according to the grade of cardiac function. A total of 32 subjects with normal physical examination during the same period were selected as the control group. Serum levels of BA, IL-6, TNF-α, pro-BNP, LVEDD and LVEF were measured respectively. Results There were significant differences in IL-6, TNF-α, BA, pro-BNP, LVEDD and LVEF between the three groups (all P<0.05), which were significantly higher in CHF group than those of control group, and which were increased with the increase of cardiac function grade (P<0.05). The value of LVEF was significantly lower in CHF group than that of control group, and which was decreased with the increase of cardiac function grade (P<0.05). There were positive correlations between BA, IL-6, TNF-α, pro-BNP and LVEDD (P<0.05). There was a negative correlation between BA and LVEF (P<0.05). Conclusion Serum BA level is correlated with inflammation and ventricular remodel, and which has a certain reference value for the evaluation of cardiac function in elderly patients with CHF .
