Ulinastatin can reduce the inflammation response after laparoscopic colectomy:a propensity score match-ing study
10.3969/j.issn.1006-5725.2018.12.033
- VernacularTitle:乌司他丁减轻腹腔镜结肠癌根治术后炎症反应:基于倾向评分匹配的回顾性研究
- Author:
Yonggang WANG
1
;
Murong HE
;
Chunshui LIN
Author Information
1. 南方医科大学南方医院麻醉科
- Keywords:
ulinastatin;
laparoscopic surgery;
colon cancer;
inflammation
- From:
The Journal of Practical Medicine
2018;34(12):2053-2057
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ulinastatin on postoperative clinical outcomes in pa-tients undergoing elective laparoscopic colectomy. Methods 454 patients underwent elective laparoscopic colecto-my from January 2015 to September 2017 were included in this retrospective study. Patients were divided into 2 groups:ulinastatin group and control group. Propensity score matching was applied to balance the preoperative baseline differences between 2 groups. 155 patients in each group were successfully matched. Mixed linear model was used to exam the effect of ulinastatin on various clinical indicators within 3 days after the surgery,including in-flammation indicators(white blood cell counts,C reactive protein),liver function indicators(alanine transami-nase,aspartate transaminase,total bilirubin),renal function indicators(serum creatinine,blood urea nitrogen). Postoperative hospital length of stay was compared between 2 groups using student's t-test. Results Ulinastatin group showed significantly reduced postoperative white blood cell count and ? reactive protein level (P = 0.036 and 0.025)compared with the control group. The average mean inhibitory effects were 1.04×109/L and 23.93 mg/L respectively,which was 11.1% and 29.9% lower than that of the control group. Procalcitonin,transaminases,total bilirubin,serum creatinine,blood urea nitrogen levels and postoperative hospital length of stay showed no signifi-cant difference between the two groups(P > 0.05). Conclusion Ulinastatin can significantly reduce the level of inflammation response after laparoscopic colectomy,which is beneficial to the fast recovery.
