Relationship between plasma sclerostin and radiographic severity of knee osteoarthritis

VernacularTitle:血浆硬化蛋白浓度与膝关节骨关节炎软骨退变程度的相关性
Author: Ruiquan TAN ¹ ; Shufen SUN ; Liping PENG ; Lixin WANG
Author Information

1. 深圳市中医院骨科广东深圳518033
Keywords: knee; osteoarthritis; plasma; sclerostin; Kellgrene&Lawrence classification
From: The Journal of Practical Medicine 2018;34(3):443-445
CountryChina
Language:Chinese
Abstract: Objective To investigated the relationship between plasma sclerostin(SOST)and knee osteoar-thritis(KOA). Methods A total of 95 patients with KOA and 95 healthy people were involved.Plasma sclerostin, CTX-II, AGG1 and AGG2 levels were measured by ELISA. The 95 patients were divided based on Kellgren-Law-rence classification. The correlation between plasma SOST level and KL classification, CTX-II, AGG1 and AGG2 were analyzed.Results Plasma SOST level in KOA was significantly lower than that in control group(P<0.001). SOST level was negatively correlated with KL grade (r =-0.828,P < 0.001),also with CTX-II (r =-0.917,P <0.001),AGG1 (r =-0.658,P < 0.001) and AGG2 (r =-0.583,P < 0.001). Conclusions SOST level in KOA patients is related to the degree of cartilage degeneration. Thus, it helps to monitor the progress and evaluate the severity of the KOA.