Expression of IL-18 in sepsis-associated thrombocytopenia and its clinical significance
10.3969/j.issn.1006-5725.2018.02.011
- VernacularTitle:白细胞介素-18在脓毒症血小板减少症中的表达及临床意义
- Author:
Jian LI
1
;
Hua XU
;
Bing WANG
;
Yongqiang WANG
Author Information
1. 天津市第一中心医院重症医学科/天津市急救医学研究所 天津300192
- Keywords:
IL-18;
sepsis;
thrombocytopenia
- From:
The Journal of Practical Medicine
2018;34(2):205-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of IL-18 in severe sepsis and sepsis-associated throm-bocytopenia and explore its clinical significance.Methods Real-time polymerase chain reaction was applied to de-tect the expression of IL-18 miRNA in 28 samples of sepsis-associated thrombocytopenia patients and 32 samples of severe sepsis. The enzyme-linked immunosorbent assay was applied to detect the concentration of IL-18 in their plasma. Results The miRNA expression of IL-18 in the sepsis-associated thrombocytopenia group was higher than in the severe sepsis group(P=0.015).The concentration of IL-18 in the severe sepsis-associated thrombocyto-penia group were also higher than those in the severe sepsis group(P=0.034). Conclusion The expression level of IL-18 is related with the severity of thrombocytopenia in patients with sepsis and is likely to play an important role in the pathogenesis of sepsis-associated thrombocytopenia.
