Correlation study between Hcy and blood lipid level and its diagnostic value in patients with cerebral infarction
10.3969/j.issn.1006-5725.2017.22.036
- VernacularTitle:脑梗死患者同型半胱氨酸与血脂相关性及其诊断价值
- Author:
Xing FANG
1
;
Ying JIANG
;
Liyu OU
;
Wujian LIANG
;
Zhenbin CAO
Author Information
1. 广西中医药大学附属瑞康医院神经内科
- Keywords:
cerebral infarction;
homocysteine;
lipid;
correlation;
diagnostic test
- From:
The Journal of Practical Medicine
2017;33(22):3819-3821
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between Hcy and blood lipid level and its diagnostic value in patients with cerebral infarction.Methods 218 patients with cerebral infarction were divided into the cerebral infarction group and no cercbral infarction group,based on the diagnosis results of head CT or MRI,and 60 healthy individuals were used as the control group.The levels of serum TC,TG,HDL-c,LDL-c and serum Hcy were determined in each group.The level of serum Hcy was used as a diagnostic-test and the criterion of cerebral infarction which was diagnosed by using head CT or MRI was used as a gold standard.Meanwhile,the sensibility,specificity,predictive value and likelihood ratio of Hcy were measured in patients with and without cerebral infarction.Results Levels of TC and Hcywere significantly elevated (P ＜ 0.01),but HDL-c level was significantly decreased in patients with and without cerebral infarction compared with the healthy people (P ＜ 0.05).Hcy level was shown negatively correlated with HDL-c (r =-0.144,P ＜ 0.05).The sensibility and specificity of Hcy in both two groups of patients with and without cerebral infarction were 42.20％ and 54.13％,the positive predictive value and negative predictive value of Hcy were 47.92％ and 48.36％,the positive likelihood ratio and negative likelihood ratio of Hcy were 0.92 and 1.07,respectively.Conclusion Hcy and blood lipid have definite correlation,but Hcy has low diagnostic value for cerebral infarction and may not be used as a biological marker for the cerebral infarction diagnosis.
