Abnormal expression of miR-132 in peripheral blood mononuclear cells and plasma of the patients with oral lichen planus and its clinical significance

VernacularTitle:口腔扁平苔藓患者外周血单个核细胞和血浆中miR-132的异常表达及其临床意义
Author: Xuefen CHEN ¹ ; Xiaofeng SUN
Author Information

1. 南京医科大学附属无锡同仁国际康复医院口腔科
Keywords: Oral lichen planus (OPL); miR-132; Peripheral blood mononuclear cells (PBMCs); MicroRNA
From: Journal of Practical Stomatology 2017;33(6):812-815
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression of miR-132 in peripheral blood mononuclear ceils(PBMCs) and plasma of patients with oral lichen planus (OLP) and the relationship of miR-132 with clinical forms of OLP.Methods:40 OLP patients (24 nonerosive OLP,16 erosive OLP) and 40 healthy controls were included.The relative expression of miR132 in peripheral blood mononuclear cells (PBMCs) and plasma was examined by quantitative real-time PC R.Results:The expression of miR-132 in both PBMCs and plasma of OLP patients was significantly higher than those in healthy controls(P ＜ 0.01).miR-132 expression of PBMCs and plasma in erosive OLP group was significantly higher than that in non-erosive OLP group and healthy control(P ＜ 0.01).However,the expression of miR-132 in PBMCs and plasma showed no significant difference between non-erosive OLP group and healthy control (P ＞0.05).Conclusion:miR-132 might be involved in the abnormal immune response of OLP patients,and miR-132 can be utilized as an assistant biomarker for the evaluation of the severity of OLP.