Enhanced efficiency of stannous penetration and lipopolysaccharide neutralization by a novel stabilized stannous-containing sodium fluoride dentifrice
10.3969/j.issn.1001-3733.2017.06.010
- VernacularTitle:一种新型含稳定亚锡-氟化钠牙膏的菌斑渗透率和脂多糖中和效率的临床评价
- Author:
Linhua LIU
1
;
Yunming SHI
;
Hongmei LI
;
Tao HE
;
Jiahui LI
;
Yanyan HE
;
Ross STRAND
;
Weili DONG
Author Information
1. 430079武汉,武汉大学口腔医学院,口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室
- Keywords:
Plaque;
Stannous;
Lipopolysaccharide;
Endotoxin;
CLSM
- From:
Journal of Practical Stomatology
2017;33(6):758-762
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the dental biofilm penetration efficiency of a novel stabilized stannous-containing sodium fluoride dentifric(EXP) and its lipopolysaccharide (LPS) neutralization efficiency.Methods:A controlled,randomized,examiner-blind in situ clinical trial was conducted with the treatment of PBS(control),EXP and a marketed stannous-containing sodium fluoride dentifrice (MKD).Fluorescent dye,fluorescent probe and fluorescence colocalization were used for sample examination and analysis.Results:EXP offered better stannous penetration into the biofilm than MKD and PBS(P ＜0.05),as well as greater LPS neutralization efficiency(P ＜0.05).There was a 96.52％ overlap of stannous ions and bounded LPS at the same sites treated by EXP.Conclusion:EXP is more effective than MKD in the delivery of stannous into the biofilm and in the neutralization of LPS.
