Expression of long noncoding RNA in papillary thyroid carcinoma with Hashimoto's thyroiditis
10.3760/cma.j.issn.1674-6090.2018.01.007
- VernacularTitle:长链非编码RNA在桥本甲状腺炎合并甲状腺乳头状癌中的表达研究
- Author:
Yu ZHANG
1
;
Jinwang DING
;
Dingcun LUO
;
You PENG
;
Wo ZHANG
;
Gang PAN
;
Daojun YU
Author Information
1. 浙江省杭州市第一人民医院肿瘤外科
- Keywords:
Hashimoto's thyroiditis;
Papillary thyroid carcinoma;
Long noncoding RNA;
Microarray
- From:
Chinese Journal of Endocrine Surgery
2018;12(1):24-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze long noncoding RNAs (lncRNAs) expression profiles in papillary thyroid carcinoma (PTC) with Hashimoto's thyroiditis (PTC-HT,group A) and PTC only (PTC,group B).Methods 55 cases of thyroid species were collected.High-throughput microarray lncRNh was used to detect the expression difference of lncRNAs between group A and group B.Real-time quantitative PCR (QRT-PCR) was used to verify.Results 1031 lncRNAs and 1338 mRNAs were detected abnormally expressed in tissue samples of group A compared to B.GO and Pathway analysis of mRNAs suggested some biological processes changed obviously,such as immune system and immune reaction.QRT-PCR showed that the expression of uc002stn.1,ENST00000452578 and uc002sti.1 in group A and group B was significantly different.Conclusion IncRNAs expression was significantly different in PTC with or without HT,which may play important roles in the pathogenesis of PTC with HT.
