TNF-α and IFN-γin tear of patients with primary pterygium
10.3980/j.issn.1672-5123.2018.2.45
- VernacularTitle:原发性翼状胬肉患者泪液中TNF-α和IFN-γ的表达
- Author:
Yan CHENG
1
;
Xian-Ning LIU
;
Jie WU
;
Xiang-Hua XIAO
;
Shi-Yin PAN
;
Xiu-Ping ZHU
Author Information
1. 710002,中国陕西省西安市第一医院眼科 陕西省眼科研究所 陕西省眼科学重点实验室
- Keywords:
tumor necrosis factor alpha;
interferon gamma;
primary pterygium
- From:
International Eye Science
2018;18(2):376-378
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the roles of tumor necrosis factor alpha ( TNF-α) , interferon gamma ( IFN-γ) in pathogenesis of primary pterygium and to explore the mechanism of tears in pterygium.?METHODS: Concentrations of TNF-α and interferon gamma IFN - γ were quantified by enzyme - linked immunosorbent assay ( ELISA ) in asymptomatic control group (30 eyes of 30 healthy volunteers) and 60 primary pterygium patients ( 30 eyes of the 30 progressive cases, 30 eyes of the 30 quiescent cases) . The data was analyzed by analysis of variance.?RESULTS:The concentration of TNF-αand IFN-γin the patients with primary pterygium were statistically significant (P<0. 05), compared with the normal control group. Tear concentration of TNF-α was significantly higher in primary pterygium compared with the control group. Tear concentration of IFN - γ was significantly reduced in primary pterygium compared with the control group (P<0. 05).?CONCLUSION:TNF-α and IFN-γmay be important in the pathogenesis and development of pterygium tissues.It can provide some new directions and ideas for the treatment of primary pterygium.
