Clinical value of anti-HBc quantification for chronic HBV infection
10.3969/j.issn.1001-5256.2018.05.001
- VernacularTitle:慢性HBV感染者抗-HBc定量检测的临床意义
- Author:
Fengqin HOU
1
;
Guiqiang WANG
Author Information
1. 北京大学第一医院感染疾病科暨肝病中心
- Keywords:
hepatitis B,chronic;
hepatitis B antibodies;
alanine transaminase
- From:
Journal of Clinical Hepatology
2018;34(5):915-918
- CountryChina
- Language:Chinese
-
Abstract:
As the achivement of a major project during the 12th Five-year Plan Period in China,the technique of anti-HBc quantification has been approved for commercial use and holds promise for wide application in clinical practice.Chinese scholars have explored the clinical significance of anti-HBc in various aspects and found that it has great values in the assessment of natural course of chronic hepatitis B virus (HBV) infection and the baseline prediction of antiviral therapy.Studies have shown that anti-HBc is significantly positively correlated with alanine aminotransferase (ALT) and significantly associated with liver inflammation.In chronic HBV infection patients with a normal ALT level,anti-HBc can be used instead as an indicator,with great significance for the development of therapeutic strategy in such patients.
