Autophagy and its role in the pathogenesis of multiple sclerosis
10.11855/j.issn.0577-7402.2017.09.15
- VernacularTitle:自噬途径在多发性硬化发病机制中的研究进展
- Author:
Xiao-Hong GAO
1
;
Bo-Yao YUAN
;
Xin-Yan ZHANG
;
Jin ZHAO
;
Man-Xia WANG
Author Information
1. 730000,兰州 兰州大学第二医院神经内科
- Keywords:
autophagy;
multiple sclerosis;
immune System
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(9):833-837
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy generally reside in eukaryote and is a highly conserved protein degradation pathway,which take part in the maintenance of cellular homeostasis as well as the growth of cells.The characterization of autophagy being reported over years has revealed that it involved in immune response,such as removal of intracellular bacteria,inflammatory cytokine secretion,antigen presentation,and lymphocyte development,and then involved in the pathogenesis of multiple sclerosis indirectly.So,in this review,we focus on the pathway ofautophagy and the role of which in the multiple sclerosis (MS) in order to further understand the important effect and potential therapeutic value of autophagy in MS.
