Epithelial mesenchymal transition in airway remodeling of asthma and its molecular regulation
10.11817/j.issn.1672-7347.2018.05.016
- VernacularTitle:哮喘气道重塑中上皮间质转化及其分子调控
- Author:
Xiaohua ZHU
1
;
Qiugen LI
Author Information
1. 南昌大学研究生院;江西省儿童医院呼吸科
- Keywords:
asthma;
airway remodeling;
epithelial mesenchymal transition;
molecular regulation
- From:
Journal of Central South University(Medical Sciences)
2018;43(5):566-570
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic inflammatory disease of the airway.Repeated inflammatory injury and tissue repair can lead to airway remodeling.The airway epithelial mesenchymal transformation (EMT) plays an important role in airway remodeling of asthma.Various cytokines and signaling pathways,such as transforming growth factor β (TGF-β),nuclear factor-kappa B (NF-κB) and bromodomain-containing protein 4 (BRD4),are involved in the molecular regulation of EMT.
