Clinical efficacy of stereotactic radiation therapy combined with temozolomide on recurrent brain glioma
10.11817/j.issn.1672-7347.2018.04.009
- VernacularTitle:立体定向放射治疗联合替莫唑胺治疗复发性脑胶质瘤的疗效
- Author:
Huiping ZHAO
1
;
Sha LIU
;
Chengchuan JIANG
;
Xiangjun LI
;
Sanyuan TANG
Author Information
1. 湖南省脑科医院肿瘤科
- Keywords:
brain glioma;
recurrence;
stereotactic radiotherapy;
temozolomide;
clinical efficacy
- From:
Journal of Central South University(Medical Sciences)
2018;43(4):394-397
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of stereotactic radiation therapy combined with temozolomide on recurrent glioma.Methods:A total of 36 patients with recurrent glioma were retrospectively analyzed and divided into a control group (n=12),who received stereotactic radiation therapy,and an experimental group (n=24),who received stereotactic radiation therapy plus temozolomide.The clinical efficacy and adverse reactions for the 2 groups were compared.Results:Total effective rate and local control rate for clinical treatment were 66.67％ and 93.94％,respectively.Late adverse reaction was not observed.The effective rate and local control rate in the experimental group were 77.27％ and 95.45％,which were slight higher than those in the control group,with no statistical significance (P＞0.05).The 0.5-,1-,2-,3-year follow-up total survival rates were 90.91％,63.64％,42.42％,and 15.15％,respectively.The 0.5-,1-,2-,3-year follow-up survival rates in the experimental group were 95.45％,72.72％,54.54％ and 22.73％,respectively,while those in the control group were 81.82％,45.45％,18.18％,and 0％,respectively.Survival analysis showed the survival time for the experimental group was significantly longer than that of the control group (30.00 months vs 14.00 months,P=0.010).Conclusion:Stereotactic radiation therapy combined with temozolomide for recurrent glioma is effective,and it has positive effect on improving the clinical efficacy and survival rate for the patients.
