Anti-tumor effect of histone deacetylase inhibitors
10.3760/cma.j.issn.1673-422X.2017.10.008
- VernacularTitle:组蛋白去乙酰化酶抑制剂的抗肿瘤作用
- Author:
Sa XIAO
1
;
Ling LI
;
Mingzhi ZHANG
Author Information
1. 450000,郑州大学第一附属医院肿瘤科
- Keywords:
Epigenesis,genetic;
Neoplasms;
Histone deacetylase inhibitors
- From:
Journal of International Oncology
2017;44(10):754-757
- CountryChina
- Language:Chinese
-
Abstract:
Histone deacetylase (HDAC) is a kind of protease,which plays an important role in the structural modification of chromosomes and the regulation of gene expression.Its excessive expression in cancer cells causes acetylation imbalance,which is closely related to the occurrence of tumor.The high efficiency and low toxicity of histone deacetylase inhibitor (HDACi) has been widely recognized as anti-tumor drug with the deepening of the study in epigenetics.It is expected to bring more breakthroughs in the treatment of tumor.
